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Related Experiment Videos

Sheep lung lymph shunting.

R E Drake, S J Allen, J Katz

    Lymphology
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Lymph shunting from the caudal mediastinal lymph node (CMN) is uncommon in sheep. Careful surgical preparation, including ligating collateral vessels, prevents inaccurate lung lymph flow measurements due to increased venous pressure.

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    Area of Science:

    • Veterinary Medicine
    • Physiology
    • Lymphatic System Research

    Background:

    • The caudal mediastinal lymph node (CMN) in sheep possesses multiple efferent lymph vessels.
    • Cannulation of a single CMN efferent vessel for lung lymph collection may be subject to lymph shunting.
    • Increased systemic venous pressure could potentially divert lymph into the cannulated vessel, leading to artifactual increases in measured lung lymph flow.

    Purpose of the Study:

    • To investigate the occurrence of lymph shunting from the CMN into cannulated efferent vessels under conditions of elevated systemic venous pressure.
    • To determine if increased venous pressure causes lymph diversion through a cannulated CMN efferent vessel, potentially mimicking increased lung lymph flow.

    Main Methods:

    • Seven sheep underwent cannulation of caudal mediastinal lymph node (CMN) efferent lymph vessels.

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  • A balloon catheter was used to artificially increase pressure within the superior vena cava.
  • Lymph flow through the cannula was monitored during induced increases in superior vena cava pressure.

    • Main Results:

    • Lymph flow through the cannulated CMN efferent vessel increased in only one out of seven sheep during elevated superior vena cava pressure.
    • The majority of sheep did not exhibit significant lymph flow changes, suggesting minimal shunting under these conditions.

    Conclusions:

    • Lymph shunting from the CMN into cannulated efferent vessels is infrequent in sheep.
    • Meticulous surgical ligation of collateral common efferent lymph vessels effectively minimizes the risk of lymph shunting and associated measurement artifacts.