Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amines to Alkenes: Cope Elimination01:14

Amines to Alkenes: Cope Elimination

2.1K
Cope elimination reaction involves the conversion of tertiary amines to alkene using hydrogen peroxide under thermal conditions, as depicted in figure 1.
2.1K
Elimination Reactions02:25

Elimination Reactions

14.3K
A nucleophile can react with an alkyl halide to give the substitution product by displacing the halogen. Or it can function as a base to give the elimination product by deprotonation of the neighboring carbon to form an alkene. In an elimination reaction, the substrate loses two groups from adjacent carbons forming at least one π bond. The carbon attached to the halogen is called the α carbon, while the adjacent carbon is called the β carbon; hence, these reactions are called...
14.3K
Radical Formation: Elimination00:51

Radical Formation: Elimination

1.9K
Another method of radical formation is the elimination process. It is the opposite of the addition route and is driven by the instability of the radical. For example, as depicted in Figure 1, dibenzoyl peroxide yields a pair of unstable radicals upon homolysis. Given its instability, this radical spontaneously undergoes elimination via a C–C bond cleavage to form a relatively more stable phenyl radical. The mechanism involves cleavage of the bond between the α and β positions...
1.9K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

555
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
555
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement01:21

[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement

2.9K
The Cope rearrangement is classified as a [3,3] sigmatropic shift in 1,5-dienes, leading to a more stable, isomeric 1,5-diene. The reaction involves a concerted movement of six electrons, four from two π bonds and two from a σ bond, via an energetically favorable chair-like transition state.
2.9K
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction01:22

Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction

2.0K
The radical dimerization of ketones or aldehydes gives vicinal diols through a pinacol coupling reaction. However, the behavior of titanium metals used for the reaction as a source of electrons is unusual. When the reaction is carried out in the presence of titanium, diols can be isolated at low temperatures. Else titanium further reacts with diols, forming alkenes through the McMurry reaction.
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defined Nylon Oligomers Enable Mechanistic Insight Into Enzymatic Polyamide Depolymerization.

ChemSusChem·2026
Same author

Azidocoumarin Glycan Probes for Photoinduced Cross-Linking and In Situ Fluorescent Labeling.

Bioconjugate chemistry·2026
Same author

PAF15-PCNA exhaustion governs the strand-specific control of DNA replication.

Nature·2026
Same author

Diacetylene-Functionalized Glycan Mimetics for Receptor-Mediated Cluster Imprinting in Model Membranes.

Macromolecular rapid communications·2025
Same author

The importin-alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus.

The FEBS journal·2025
Same author

Highly Branched Sulfated Glycopolymers as Mucin Mimetics.

Journal of the American Chemical Society·2025
Same journal

Multitargeted Degradation of Cell Surface Receptors by Modular Glyco-Nanosheets.

ACS macro letters·2026
Same journal

Vinyl Ether Maleic Anhydride Copolymers: Efficient and Reusable Sorbents for Removing Heavy Metals from Water.

ACS macro letters·2026
Same journal

Topology-Preserving Elastic Deformation Augmentation Enables Robust Defect Detection in Data-Scarce Industrial Imagery.

ACS macro letters·2026
Same journal

Flexible Porous Organic Polymers with α,β-Enone-Linkage via AlCl<sub>3</sub>-Catalyzed Horner-Wadsworth-Emmons Polymerization for Pd Recovery.

ACS macro letters·2026
Same journal

Light-Controlled Topology Switching Enables Continuous Modulation of Thermally Induced Phase Behavior in Polymer Solutions.

ACS macro letters·2026
Same journal

Correction to "Light-Induced Transformation from Covalent to Supramolecular Polymer Networks".

ACS macro letters·2026
See all related articles

Related Experiment Video

Updated: Sep 22, 2025

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

9.3K

Cu Elimination from Cu-Coordinating Macromolecules.

Morten F Ebbesen1, Dana Itskalov1, Mischa Baier1

  • 1Heinrich-Heine-Universität Düsseldorf, Institut für Organische Chemie und Makromolekulare Chemie, Universitätsstr. 1, 40225 Düsseldorf, Germany.

ACS Macro Letters
|May 25, 2022
PubMed
Summary
This summary is machine-generated.

A new method effectively removes copper (Cu) impurities from water-soluble polymers using sodium diethyldithiocarbamate. This simple process achieves over 99.9% Cu elimination without damaging the polymers, aiding Cu-catalyzed applications.

More Related Videos

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

9.7K
Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium
13:34

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium

Published on: July 8, 2015

9.2K

Related Experiment Videos

Last Updated: Sep 22, 2025

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

9.3K
Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

9.7K
Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium
13:34

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium

Published on: July 8, 2015

9.2K

Area of Science:

  • Polymer Chemistry
  • Analytical Chemistry
  • Materials Science

Background:

  • Water-soluble polymers coordinating copper (Cu) are crucial in various applications, including Cu-catalyzed conjugation techniques.
  • Standard purification methods often struggle to efficiently remove residual Cu impurities from these macromolecules.
  • Incomplete Cu removal can hinder subsequent reactions and affect material properties.

Purpose of the Study:

  • To develop and validate a simple, fast, and efficient method for eliminating Cu impurities from water-soluble Cu-coordinating polymers.
  • To assess the efficacy of sodium diethyldithiocarbamate for Cu complexation and precipitation.
  • To confirm the integrity of the purified polymers using various analytical techniques.

Main Methods:

  • Complexation and precipitation of Cu using sodium diethyldithiocarbamate.
  • Investigation of the process on two distinct classes of water-soluble Cu-coordinating polymers.
  • Quantification of residual Cu using sensitive analytical methods.
  • Characterization of polymer integrity via 1H NMR, MALDI, ATR-IR, and SEC.

Main Results:

  • Achieved >99.9% elimination of Cu impurities.
  • Reduced residual Cu levels below the detection limit (0.0005 wt %).
  • Analytical characterization confirmed no polymer degradation or induced side reactions.

Conclusions:

  • The developed method is highly effective for removing Cu impurities from water-soluble, Cu-coordinating polymers.
  • Sodium diethyldithiocarbamate offers a mild, efficient, and scalable solution for polymer purification.
  • This technique is a valuable addition to the toolkit for preparing polymers used in Cu-catalyzed applications.