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Updated: Sep 22, 2025

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

Air bubble removal: Wettability contrast enabled microfluidic interconnects.

Xiaoxiao Zhao^1,2, Chenbo Ma¹, Daniel S Park²

¹College of Mechanical and Electrical Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, PR China.

Sensors and Actuators. B, Chemical

|May 25, 2022

Summary

This summary is machine-generated.

This study introduces a novel surface engineering method to eliminate air bubbles in microfluidic devices. By creating a sharp wettability contrast, air bubbles are filtered out, improving device reliability and preventing cell damage.

Keywords:

Air bubble removal Interconnect Microfluidics Superhydrophobic surface

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Area of Science:

Microfluidics
Surface Science
Biotechnology

Background:

Air bubbles in microfluidic devices cause pressure fluctuations, potentially damaging cells and impairing device function.
Overcoming surface tension forces is critical for air bubble removal at the microscale.

Purpose of the Study:

To develop a simple and effective strategy for eliminating air bubbles in microfluidic systems.
To engineer microfluidic interconnects with a sharp wettability contrast to manage fluid flow and prevent bubble ingress.

Main Methods:

Fabrication of microfluidic port-to-port interconnects with superhydrophobic peripheries and hydrophilic inner channels.
Utilizing the wettability contrast to guide fluid entry and filter air bubbles.

Main Results:

Demonstrated consistent air bubble elimination across various flow rates and liquid analytes.
The strategy effectively filters air bubbles at port-to-port gaps due to wettability differences.

Conclusions:

A novel wettability contrast strategy provides a simple, effective method for air bubble removal in microfluidics.
This approach offers an alternative to complex, equipment-intensive bubble removal techniques.