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Current Strategies in Treating Cytokine Release Syndrome Triggered by Coronavirus SARS-CoV-2

Long G Wang1, Luxi Wang2

  • 1Department of Research and Development, Natrogen Therapeutics International, Inc., Valhalla, NY, USA.

Immunotargets and Therapy
|May 25, 2022
PubMed

Insights

COVID-19 treatments have advanced, with immunomodulators showing promise for managing cytokine release syndrome (CRS). Further research is needed to improve these therapies against evolving SARS-CoV-2 variants.

Area of Science:

  • * Infectious Diseases
  • * Immunology
  • * Pharmacology

Background:

  • * The SARS-CoV-2 pandemic spurred significant advancements in COVID-19 treatment and management strategies.
  • * Therapeutic approaches include antiviral drugs, cell and gene therapies, immunomodulators, neutralizing antibodies, and combination therapies.
  • * Immunomodulators are the most extensively studied treatment class for COVID-19.

Purpose of the Study:

  • * To review recent progress in COVID-19 treatment strategies.
  • * To emphasize management approaches for cytokine release syndrome (CRS) in SARS-CoV-2 infections.
  • * To provide a perspective on ongoing challenges and future directions in combating COVID-19.

Main Methods:

  • * Comprehensive literature review of recent studies on COVID-19 therapeutics.
  • * Analysis of treatment efficacy, particularly for immunomodulators and antiviral small molecules.
  • * Focus on strategies targeting viral variants and inflammatory pathways.

Main Results:

  • * Small molecule antivirals and immunoregulators show potential against SARS-CoV-2 variants by targeting conserved viral regions or inflammation pathways.
  • * Immunomodulators have demonstrated benefits in reducing mortality associated with cytokine release syndrome (CRS).
  • * Ongoing viral evolution presents significant challenges to treatment efficacy and necessitates continuous research.

Conclusions:

  • * While progress has been made, further investigation into immunomodulators is crucial to enhance efficacy and minimize side effects.
  • * Developing robust treatments effective against evolving SARS-CoV-2 variants remains a critical objective.
  • * Continued research and strategic management are essential in the ongoing battle against COVID-19.
Keywords:
COVID-19antiviral drugcytokine release syndromecytokine stormimmunoregulatorsneutralizing antibodies

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