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Thyrotoxicosis after a massive levothyroxine ingestion: A case report
Fang Du1, Shi-Wei Liu2, Hua Yang3
1Department of Endocrinology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan 030009, Shanxi Province, China.
World Journal of Clinical Cases
|May 25, 2022
Summary
Excessive levothyroxine intake can cause thyrotoxicosis. Prompt medical intervention, including monitoring vital signs and specific treatments, is crucial for patient recovery from thyroid hormone overdose.
Area of Science:
- Endocrinology
- Clinical Pharmacology
Background:
- Thyrotoxicosis from exogenous thyroid hormone ingestion is rare, particularly in adults.
- Existing literature predominantly features pediatric cases.
Observation:
- A 21-year-old woman presented with symptoms of levothyroxine overdose, including palpitations, chest tightness, and loss of consciousness.
- The patient developed atrial fibrillation, a serious cardiac complication.
Findings:
- Treatment involved a multi-faceted approach: propylthiouracil to inhibit thyroid hormone conversion and synthesis, propranolol for heart rate control, and hydrocortisone for severe thyrotoxicosis.
- Hemoperfusion was utilized to enhance levothyroxine clearance from the body.
Implications:
- This case highlights the importance of vigilant monitoring of vital signs in patients with suspected thyroid hormone overdose.
- Effective and timely treatment strategies are essential for managing severe levothyroxine toxicity and ensuring patient survival.
