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Handling parametric assumptions in principal causal effect estimation using Gaussian mixtures.

Booil Jo1

  • 1Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.

Statistics in Medicine
|May 25, 2022
PubMed
Summary

This study revives parametric mixture modeling for principal stratification, offering a new approach to causal inference. It introduces a method to assess estimate quality, making principal effects more accessible.

Keywords:
Gaussian mixturescausal inferencemoving exclusion restrictionnonparametric identificationparametric mixture modelingprincipal stratification

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Area of Science:

  • Causal Inference
  • Statistical Modeling
  • Econometrics

Background:

  • Principal stratification models with continuous outcomes often use Gaussian mixture models.
  • However, parametric mixture modeling is typically avoided for identifying principal effects when nonparametric identification is not assured.
  • Assessing the quality of principal effect estimates is challenging under parametric assumptions.

Purpose of the Study:

  • To re-evaluate the utility of parametric mixture modeling in principal stratification.
  • To propose a method for assessing the quality of principal effect estimates derived from parametric mixture models.
  • To explore the potential of parametric mixture modeling as an accessible tool for causal inference.

Main Methods:

  • Utilizing Gaussian mixture models within a parametric estimation framework.
  • Employing parametric mixture modeling with and without the guarantee of nonparametric identification to assess estimation quality.
  • Implementing the moving exclusion restriction assumption, a variation of the standard exclusion restriction.

Main Results:

  • Parametric mixture modeling can be a viable approach for principal stratification, even without nonparametric identification.
  • The proposed method allows for the assessment of principal effect estimate quality.
  • The moving exclusion restriction aids in evaluating estimates from parametric mixture models.

Conclusions:

  • Parametric mixture modeling shows promise as an accessible tool for causal inference in principal stratification.
  • This approach can overcome previous limitations and expand possibilities in the field.
  • Further research can build upon these findings to refine causal inference methods.