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Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm

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Published on: May 4, 2020

[Stress, asthenia and cognitive disorders].

E E Vasenina¹, O A Gankina¹, O S Levin¹

¹Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova

|May 25, 2022

Summary

Asthenia, a sign of energy depletion, can become a disabling condition like chronic fatigue syndrome. It often co-occurs with cognitive and affective disorders, complicating diagnosis.

Keywords:

affective disorders asthenia chronic fatigue syndrome cognitive impairment treatment

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Area of Science:

Neurology
Immunology
Psychiatry

Background:

Asthenia, a common clinical syndrome, signals depleted energy resources and can stem from various somatic and neurological conditions.
It can evolve into a severe, disabling pathological state, potentially becoming chronic fatigue syndrome, an immune-mediated disease.
Asthenia frequently presents alongside affective and cognitive disorders, complicating accurate primary diagnosis.

Purpose of the Study:

To investigate the complex interrelationships between asthenia, chronic fatigue syndrome, and associated cognitive and affective disorders.
To elucidate the diagnostic challenges posed by the co-occurrence of these conditions.

Main Methods:

Review of clinical manifestations and etiological factors of asthenia.
Analysis of the progression from asthenia to chronic fatigue syndrome.
Examination of the impact of concurrent cognitive and affective disorders on diagnosis.

Main Results:

Asthenia's dual nature as a defense mechanism and a potential pathological entity is highlighted.
The transformation of asthenia into chronic fatigue syndrome, an immune-mediated condition, is discussed.
The significant diagnostic challenges arising from the frequent combination of asthenia with cognitive and affective symptoms are identified.

Conclusions:

Understanding the intricate connections between asthenia, chronic fatigue syndrome, and mental health disorders is crucial for accurate diagnosis.
Further research is needed to unravel the complex pathophysiology and improve diagnostic strategies for these overlapping conditions.