Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

In vivo dynamic hotspot-enhanced Raman spectroscopy via reconfigurable swarming nanoprobes.

Nature communications·2026

Same author

CBAM meets DropBlock: enhancing robot steering-angle prediction with hybrid attention and structured dropout.

Scientific reports·2026

Same author

Synergizing Strain and Ternary Components in Ultrathin PtCuIr-IrO<sub><i>x</i></sub> Nanodendrites to Enable the C<sub>2</sub> Pathway for Ethanol Electrooxidation.

Inorganic chemistry·2026

Same author

Phase separation of p85β modulates hepatocellular carcinoma progression through POLR1A.

International journal of biological sciences·2026

Same author

A cascade-responsive nanoplatform for cyclooxygenase-2 inhibition and inflammation regulation to enhance photoimmunotherapy.

Acta biomaterialia·2026

Same author

NIDS-Mamba: Lightweight Network Intrusion Detection for IoT Sensor Networks via State Space Models.

Sensors (Basel, Switzerland)·2026

Same journal

A two-step centrifugal microfluidic platform for semi-automated IGRA detection of tuberculosis based on chemiluminescence.

The Analyst·2026

Same journal

On-site rapid identification of animal and plant creams <i>via</i> 2D FeB nanozyme-based colorimetric sensors.

The Analyst·2026

Same journal

Sensitive detection of aflatoxin B1 using a dual-mode fluorescent aptasensor based on cascade signal amplification.

The Analyst·2026

Same journal

Deep learning-enabled microfluidic digital PCR platform for efficient seven-color quantification.

The Analyst·2026

Same journal

Monitoring food spoilage biogenic amines utilizing a blue-emitting fluorescent ionic liquid.

The Analyst·2026

Same journal

Correction: Regeneration-on-a-chip: a planarian microfluidic device enabling automated cultivation, individual tracking and <i>in vivo</i> imaging for regeneration study.

The Analyst·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 22, 2025

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Microfluidic flow cytometry for blood-based biomarker analysis.

Yuxin Zhang¹, Ying Zhao², Tim Cole¹

¹Department of Electronic, Electrical and Systems Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. S.Tang@bham.ac.uk.

|May 25, 2022

Summary

This summary is machine-generated.

Microfluidic flow cytometry (MFCM) advances single-cell analysis for point-of-care diagnostics. This review highlights MFCM progress in blood biomarker detection and discusses challenges for clinical applications.

More Related Videos

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Published on: March 8, 2024

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells

Published on: December 31, 2009

Related Experiment Videos

Last Updated: Sep 22, 2025

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Published on: March 8, 2024

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells

Published on: December 31, 2009

Area of Science:

Biomedical Engineering
Analytical Chemistry
Cell Biology

Background:

Flow cytometry offers rapid, quantitative single-cell analysis.
Microfluidics enables portable diagnostic devices for point-of-care testing (POCT).
Microfluidic flow cytometry (MFCM) integrates these technologies on-chip for advanced cell analysis and sorting.

Purpose of the Study:

To review recent advancements in microfluidic flow cytometry (MFCM) subsystems.
To summarize MFCM applications in blood-based biomarker analysis.
To identify challenges and opportunities for MFCM in blood-based POCT.

Main Methods:

Review of recent literature on microfluidic flow cytometry (MFCM) focusing, detecting, and sorting subsystems.
Analysis of MFCM applications in blood biomarker detection.
Discussion of technological challenges and commercialization potential for blood-based POCT.

Main Results:

Significant progress has been made in MFCM subsystems (focusing, detection, sorting).
MFCM has demonstrated capabilities in analyzing blood-based biomarkers for diagnostics.
Key challenges remain in integrating MFCM for widespread blood-based POCT.

Conclusions:

MFCM is a powerful tool for single-cell analysis and blood biomarker detection.
Further development is needed to overcome challenges for blood-based POCT applications.
MFCM holds commercialization potential for non-invasive diagnostic tools.