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Updated: Sep 22, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Machine Learning in Medicine: To Explain, or Not to Explain, That Is the Question
Cedric Bousquet1, Diva Beltramin2
1Sorbonne Université, Inserm, université Paris 13, Laboratoire d'informatique médicale et d'ingénierie des connaissances en e-santé, LIMICS, F-75006 Paris, France.
Abstract:
In 2022, the Medical Informatics Europe conference created a special topic called "Challenges of trustable AI and added-value on health" which was centered around the theme of eXplainable Artificial Intelligence. Unfortunately, two opposite views remain for biomedical applications of machine learning: accepting to use reliable but opaque models, vs. enforce models to be explainable. In this contribution we discuss these two opposite approaches and illustrate with examples the differences between them.
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