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Published on: June 21, 2018
Reliability of Drug-Drug Interaction Measurement on Real-Word Data: The ReMIAMes Project
Catherine Duclos1, Nicolas Griffon1,2, Christel Daniel1,2
1Sorbonne Université, Université Sorbonne Paris Nord, INSERM, Laboratoire d'Informatique Médicale et d'Ingénierie des connaissances en e-Santé, LIMICS, F-75006 Paris, France.
Abstract:
The ReMIAMes project proposes a methodological framework to provide a reliable and reproducible measurement of the frequency of drug-drug interactions (DDI) when performed on real-world data. This framework relies on (i) a fine-grained and contextualized definition of DDIs, (ii) a shared minimum information model to select the appropriate data for the correct interpretation of potential DDIs, (iii) an ontology-based inference module able to handle missing data to classify prescription lines with potential DDIs, (iv) a report generator giving the value of the measurement and explanations when potential false positive are detected due to a lack of available data. All the tools developed are intended to be publicly shared under open license.
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