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Related Experiment Video

Updated: Sep 22, 2025

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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Microservices-Based Architecture to Support the Adaptive RECORDS-Trial.

Ebrahim Nageba1, Martin Hilka1, Rafael Gozlan1

  • 1AP-HP, Information Systems Direction, Innovation and Data Department.

Studies in Health Technology and Informatics
|May 25, 2022
PubMed
Summary
This summary is machine-generated.

Platform trials require adaptable information systems. A microservices-based architecture supports adaptive clinical trials, enabling biomarker stratification and enrichment strategies for ongoing studies.

Keywords:
Adaptive Clinical-TrialBiomarker stratificationCDMSClinical DataContainerizationInteroperabilityMachin-Learning AlgorithmsMicroservices-based ArchitecturePlatform TrialseCRF

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Area of Science:

  • Clinical informatics
  • Biomedical data management

Background:

  • Existing clinical data management systems (CDMS) lack flexibility for evolving trial needs.
  • Platform trials and adaptive clinical trials necessitate dynamic information system architectures.

Purpose of the Study:

  • To present a microservices-based architecture for adaptive clinical trials.
  • To address the limitations of traditional CDMS in supporting trial modifications.

Main Methods:

  • Development of a microservices-based architecture.
  • Implementation of the architecture in the RECORDS-Trial platform.
  • Focus on enabling biomarker stratification and enrichment strategies.

Main Results:

  • The proposed architecture successfully supports the adaptive RECORDS-Trial.
  • The system accommodates changes not predefined in the trial design.
  • Facilitates essential adaptive trial operations like biomarker stratification.

Conclusions:

  • A microservices architecture is a viable solution for adaptive clinical trials.
  • This approach enhances the flexibility of information systems in clinical research.
  • Enables advanced strategies crucial for modern trial designs.