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Updated: Sep 22, 2025

Establishment of a Clinic-based Biorepository
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Building an i2b2-Based Population Repository for COVID-19 Research.

Miguel Pedrera-Jimenez1,2, Noelia Garcia-Barrio1, Gema Hernandez-Ibarburu3

  • 1Data Science Unit, Research Institute Hospital 12 de Octubre, Madrid, Spain.

Studies in Health Technology and Informatics
|May 25, 2022
PubMed
Summary
This summary is machine-generated.

Hospital Universitario 12 de Octubre standardized Electronic Health Records (EHRs) for COVID-19 data. This enabled sharing over 200,000 cases with global research networks, advancing pandemic research.

Keywords:
4CE ConsortiumCOVID-19Data ReusabilityElectronic Health RecordsReal World DataSemanticsStandardized repositoriesTriNetXi2b2

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Area of Science:

  • Health Informatics
  • Epidemiology
  • Medical Data Management

Background:

  • Effective reuse of Electronic Health Records (EHRs) for diseases like COVID-19 necessitates adherence to international data standards.
  • The COVID-19 pandemic highlighted the need for agile and standardized data management in healthcare.

Purpose of the Study:

  • To describe the process of evolving Electronic Health Records (EHRs) at Hospital Universitario 12 de Octubre (H12O) for COVID-19 data.
  • To enable the sharing of standardized COVID-19 patient data with international research consortia.

Main Methods:

  • Identification, modeling, and standardization of COVID-19 related concepts within the EHR system.
  • Agile, flexible, and staged evolution of EHRs to accommodate new disease data.
  • Extraction, transformation, and loading (ETL) of data into an i2b2 repository.
  • Data sharing via platforms like TriNetX and the 4CE Consortium.

Main Results:

  • Standardized data from over 200,000 COVID-19 cases were successfully processed.
  • H12O's EHRs were adapted to meet international standards for disease-specific data reuse.
  • Facilitated data contribution to global COVID-19 research efforts.

Conclusions:

  • Agile and standardized EHR evolution is crucial for managing and sharing critical health data during pandemics.
  • The i2b2 repository and international collaborations enabled significant data sharing for COVID-19 research.
  • H12O's approach provides a model for other institutions handling large-scale disease data.