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A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
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Tuberculosis Drug Discovery: Challenges and New Horizons
Guilherme F S Fernandes1, Andrew M Thompson2, Daniele Castagnolo1
1Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.
Journal of Medicinal Chemistry
|May 25, 2022
Summary
Tuberculosis (TB) remains a major global health threat, causing millions of deaths annually. This review examines promising new TB drugs and highlights challenges in developing effective treatments to combat this ancient infectious disease.
Area of Science:
- Infectious Diseases
- Microbiology
- Drug Discovery
Background:
- Tuberculosis (TB) is a leading infectious killer, claiming 1.5 million lives in 2020.
- The World Health Organization (WHO) emphasizes the urgent need for new TB drugs.
- Despite recent advances, few novel TB drug candidates successfully reach clinical development.
Purpose of the Study:
- To critically review anti-TB compounds with proven in vivo efficacy against Mycobacterium tuberculosis from the last six years.
- To identify key challenges and successful strategies in developing new TB drugs.
- To outline the current global pipeline of TB drug candidates in clinical studies.
Main Methods:
- Literature review of scientific publications on anti-TB compounds.
- Analysis of in vivo efficacy data for Mycobacterium tuberculosis.
- Assessment of clinical trial pipelines for TB drug candidates.
Main Results:
- Hundreds of novel anti-TB molecules are reported annually, but few advance.
- Compounds demonstrating significant in vivo efficacy are identified and reviewed.
- Key hurdles in TB drug development and successful strategies are highlighted.
Conclusions:
- A renaissance in TB drug discovery is underway, with numerous candidates in trials.
- Overcoming development challenges is crucial for advancing new TB therapies.
- Further research and investment are needed to address the global TB burden.
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