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Updated: Sep 22, 2025
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
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Asymmetric C(sp3)-H borylation: an update
Sumit Ghosh1, Anogh Ghosh1, Pranjal Pyne1
1Department of Chemistry, Visva-Bharati (A Central University), Santiniketan 731235, India. alakananda.hajra@visva-bharati.ac.in.
Organic & Biomolecular Chemistry
|May 25, 2022
Summary
Chiral organoboronates are vital for pharmaceuticals and materials. This review details recent advances in transition metal-catalyzed asymmetric C(sp3)-H borylation, a key synthetic strategy.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Methodology
Background:
- Chiral organoboronates are crucial building blocks in pharmaceuticals and materials science.
- Traditional synthetic methods often lack efficiency and versatility.
- Asymmetric catalysis offers a practical and beneficial strategy for preparing chiral compounds.
Purpose of the Study:
- To provide a comprehensive overview of transition metal-catalyzed asymmetric C(sp3)-H borylation.
- To analyze recent progress and developments in this synthetic field.
- To highlight the utility of generated carbon-boron bonds.
Main Methods:
- Focus on asymmetric catalysis for C-H functionalization.
- Review of transition metal-catalyzed borylation reactions.
- Analysis of strategies for aliphatic C(sp3)-H borylation.
Main Results:
- Significant progress has been made in aliphatic C-H borylation.
- Carbon-boron bonds are versatile intermediates for C-C, C-N, and C-O bond formation.
- The review covers developments up to March 2022.
Conclusions:
- Transition metal-catalyzed asymmetric C(sp3)-H borylation is a rapidly advancing field.
- This methodology provides efficient access to valuable chiral organoboronates.
- Continued research promises further innovations in synthetic chemistry.
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