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Updated: Sep 22, 2025

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
Published on: January 20, 2022
ESI and tandem MS for mechanistic studies with high-valent transition metal species
Katharina Bleher1, Peter Comba1,2, Jürgen H Gross3
1Universität Heidelberg, Anorganisch-Chemisches Institut, INF 270, D-69120 Heidelberg, Germany. peter.comba@aci.uni-heidelberg.de.
Abstract:
The analysis of high-valent metal species has been in the focus of research for over 20 years. Mass spectrometry (MS) represents a technique routinely used for their characterization, in particular electrospray ionization mass spectrometry (ESI-MS) and cold-spray ionization-mass spectrometry (CSI-MS). The combination of both methods with tandem MS provides additional tools for understanding decay processes and reaction pathways. In this Perspective, tandem ESI-MS, an important instrument in enzyme and peptide characterization and organometallic chemistry, is discussed as a valuable tool for the elucidation of reaction mechanisms of high-valent metal species.
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