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Impact of High Cardiovascular Risk on Hospital Mortality in Intensive Care Patients Hospitalized for COVID-19

Bruno Ferraz de Oliveira Gomes1,2, João Luiz Fernandes Petriz1, Iliana Regina Ribeiro Menezes1

  • 1Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil.

Arquivos Brasileiros De Cardiologia
|May 25, 2022
PubMed

Insights

High cardiovascular risk (HCR) significantly increases in-hospital mortality for COVID-19 patients in intensive care, but only when accompanied by myocardial injury. This finding highlights the critical interplay between cardiovascular health and COVID-19 severity.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Studies indicate a higher mortality rate in COVID-19 patients with cardiovascular risk factors (CRF).
  • Understanding the specific impact of high cardiovascular risk (HCR) in critically ill COVID-19 patients is crucial.

Purpose of the Study:

  • To evaluate the influence of HCR on in-hospital mortality among intensive care unit (ICU) patients diagnosed with COVID-19.

Main Methods:

  • A retrospective study analyzed 236 ICU patients with confirmed COVID-19 and troponin measurements.
  • HCR was defined by pre-existing cardiovascular disease, diabetes, chronic kidney disease, or multiple CRFs.
  • All-cause in-hospital mortality was the primary outcome, with logistic regression adjusting for severity.

Main Results:

  • Nearly half of the patients (47.4%) had HCR. Mortality increased significantly with the number of CRFs (p=0.001).
  • HCR combined with myocardial injury showed a substantially higher in-hospital mortality (OR 40.38).
  • Myocardial injury alone was also significantly associated with mortality in patients without HCR (OR 16.7).

Conclusions:

  • In critically ill COVID-19 patients, HCR is a significant predictor of in-hospital mortality, but this association is contingent upon the presence of myocardial injury.
  • Myocardial injury is a key factor mediating the increased mortality risk in COVID-19 patients with HCR.
Abstract

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