Related Experiment Video
Updated: Sep 22, 2025
11:39
Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
Published on: July 21, 2017
31.5K
Crosstalk between cilia and autophagy: implication for human diseases
Manuela Morleo1,2, Helena L A Vieira3,4,5, Petra Pennekamp6,7
1Telethon Institute of Genetics and Medicine (TIGEM), 80078, Pozzuoli, Italy.
Autophagy
|May 25, 2022
Summary
Autophagy, a cellular recycling process, and cilia, cell structures with sensory roles, are interconnected. Understanding this interplay is crucial for treating ciliopathies and autophagy-related diseases.
Area of Science:
- Cell Biology
- Molecular Biology
Background:
- Autophagy is a vital cellular process for energy homeostasis, crucial during development and nutrient stress.
- Dysfunctional autophagy is implicated in various pathologies.
- Cilia are microtubule-based organelles involved in cell motility and sensing; their defects cause ciliopathies.
Approach:
- This review synthesizes current research on the bidirectional relationship between autophagy and cilia.
- It examines emerging molecular players, including lysosomal and mitochondrial proteins, in this axis.
- The review discusses contradictory findings and highlights the need for further mechanistic understanding.
Key Points:
- Selective autophagic degradation regulates ciliogenesis, while cilia influence autophagic activity.
- The interplay involves various cellular components, including lysosomes and mitochondria.
- The molecular mechanisms governing the autophagy-cilia axis are complex and not fully elucidated.
Conclusions:
- The autophagy-cilia axis is a critical area of research with significant implications for human health.
- Further investigation is needed to resolve conflicting data and understand the underlying molecular mechanisms.
- Insights into this axis could lead to novel therapeutic strategies for ciliopathies and autophagy-associated disorders.
Related Concept Videos
01:27Autophagy
4.6K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.6K
01:36Delivery Pathways to the Lysosome
7.5K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
7.5K
01:22Microtubules in Signaling
1.8K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.8K
01:05Mechanism of Ciliary Motion
4.0K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
4.0K
01:18Autophagic Cell Death
3.6K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
3.6K
03:03mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K