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Supramolecular materials based on AIEgens for photo-assisted therapy
Xin-Yue Lou1, Ge Zhang1, Nan Song2
1International Joint Research Laboratory of Nano-Micro Architecture Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, PR China.
Biomaterials
|May 25, 2022
Summary
Aggregation-induced emission luminogens (AIEgens) are advanced materials for light-activated therapies. Supramolecular assembly enhances their biocompatibility and therapeutic functions for precise theranostics.
Area of Science:
- Nanomedicine
- Theranostics
- Supramolecular Chemistry
Background:
- Photo-assisted therapy offers noninvasive, precise treatments with deep tissue penetration.
- Aggregation-induced emission luminogens (AIEgens) are fluorescent materials with light-activated therapeutic potential.
Purpose of the Study:
- To review the design and fabrication of AIEgen-based supramolecular materials for photo-assisted therapies.
- To explore how supramolecular self-assembly enhances AIE materials for theranostic applications.
Main Methods:
- Summarizing AIEgen-based self-assembled materials based on supramolecular driving forces.
- Describing structural and therapeutic features of these materials.
- Reviewing applications in photothermal therapy, photodynamic therapy, and photo-induced reactions.
Main Results:
- Supramolecular self-assembly improves AIE materials' biocompatibility, specificity, and responsiveness.
- AIEgen-based supramolecular materials show potential for enhanced and controllable multimodal theranostics.
- The review categorizes materials by supramolecular driving forces, detailing their properties and therapeutic effects.
Conclusions:
- AIEgen-based supramolecular materials offer tunable physicochemical properties for optimized therapeutic functions.
- These materials open possibilities for advanced, controllable multimodal theranostic strategies.
- Further research is needed to address remaining challenges in this field.
Keywords:
Aggregation-induced emissionNanomedicinePhoto-assisted therapySelf-assemblySupramolecular materials
