Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

2.8K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.8K
Asepsis01:28

Asepsis

2.4K
The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
2.4K
Standard Precaution01:26

Standard Precaution

2.2K
Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
2.2K
Methods for Controlling Microbial Growth01:29

Methods for Controlling Microbial Growth

541
Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
541
Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

7.4K
Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
7.4K
Key Techniques in Microbiology01:29

Key Techniques in Microbiology

597
Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
597

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Manganese-Catalyzed Formate Synthesis via Coupled Methanol Dehydrogenation and Bicarbonate Reduction.

Inorganic chemistry·2026
Same author

Optimization of Fe(III)-based negative electrodes for lithium-ion batteries: probing electrochemical performance and stability characteristics.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

Language-like properties in the vocal behavior of animals.

Current opinion in neurobiology·2026
Same author

DRDarkNet: a hybrid deep feature engineering model for accurate autopsy image classification.

International journal of legal medicine·2026
Same author

Bioinspired Manganese Catalyzed Direct Deamination of Primary Amines With Water Forming Carboxylic Acids and Ketones.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Neural activity flows through cortical subnetworks during speech production.

Cell reports·2026

Related Experiment Video

Updated: Sep 22, 2025

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
09:30

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

3.7K

Interventions Risk Evaluation and Management in Aseptic Manufacturing.

Hal Baseman1, Subrata Chakraborty2, Michael A Long1

  • 1ValSource, Inc., 918A Horseshoe Pike, Downingtown, PA 19335; and.

PDA Journal of Pharmaceutical Science and Technology
|May 25, 2022
PubMed
Summary

Personnel interventions pose a risk of microbiological contamination in aseptic biopharmaceutical manufacturing. This study introduces an Intervention Risk Evaluation Model (IREM) to objectively assess and mitigate these contamination risks, enhancing product sterility assurance.

Keywords:
Aseptic process simulationAseptic processingInterventionMedia fillQuality risk managementRisk Assessment

More Related Videos

Evaluation of the Impact of a New Cooling Cell Processor System on Islet Cell Isolation Facility
05:21

Evaluation of the Impact of a New Cooling Cell Processor System on Islet Cell Isolation Facility

Published on: August 11, 2023

330
Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface
07:00

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Published on: August 11, 2017

8.3K

Related Experiment Videos

Last Updated: Sep 22, 2025

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
09:30

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

3.7K
Evaluation of the Impact of a New Cooling Cell Processor System on Islet Cell Isolation Facility
05:21

Evaluation of the Impact of a New Cooling Cell Processor System on Islet Cell Isolation Facility

Published on: August 11, 2023

330
Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface
07:00

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Published on: August 11, 2017

8.3K

Area of Science:

  • Pharmaceutical Manufacturing
  • Microbiology
  • Risk Assessment

Background:

  • Aseptic processes are critical for sterile biopharmaceutical production.
  • Personnel interventions are a significant source of microbial contamination.
  • Understanding contamination risks informs process design and validation.

Purpose of the Study:

  • To present a philosophy and method for objective intervention risk determination.
  • To introduce the Intervention Risk Evaluation Model (IREM).
  • To improve aseptic process design, operation, and sterility assurance.

Main Methods:

  • Development of the Intervention Risk Evaluation Model (IREM).
  • Utilizing a keyword approach to identify, measure, and evaluate risk factors.
  • Illustrating the model's development with a case study.

Main Results:

  • The IREM provides an objective, accurate, and useful method for risk assessment.
  • The model aims to standardize intervention risk evaluation.
  • Implementation can lead to increased operator awareness and reduced contamination risk.

Conclusions:

  • The IREM enhances objectivity in aseptic process risk assessment.
  • Implementing the IREM can improve sterility assurance levels.
  • Operator awareness of risks is crucial for reducing contamination.