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Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

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Machine learning identifying peripheral circulating metabolites associated with intraocular pressure alterations.

Chaoxu Qian^1,2, Simon Nusinovici^1,3, Sahil Thakur¹

¹Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

The British Journal of Ophthalmology

|May 25, 2022

Summary

Researchers identified key blood metabolites linked to intraocular pressure (IOP). Findings show associations between albumin, glucose, lactate, glutamine, and cholesterol esters with IOP, offering insights into its control mechanisms.

Keywords:

Glaucoma Intraocular pressure

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Last Updated: Sep 22, 2025

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Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

Area of Science:

Ophthalmology
Metabolomics
Population Health

Background:

Intraocular pressure (IOP) is a critical risk factor for glaucoma.
Identifying blood-based biomarkers for IOP can aid in understanding its underlying pathophysiology.
Previous research has explored various factors, but a comprehensive metabolomic analysis in diverse Asian populations is lacking.

Conclusions:

Several novel blood metabolites are significantly associated with intraocular pressure.
These identified metabolites may serve as potential biomarkers for IOP.
The findings contribute to understanding the complex metabolic pathways influencing IOP regulation.