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CCR5 closes the temporal window for memory linking.

Yang Shen1, Miou Zhou2,3, Denise Cai1,4

  • 1Neurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.

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|May 25, 2022
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This summary is machine-generated.

The brain uses C-C chemokine receptor type 5 (CCR5) to control how long memories can be linked over time. Increased CCR5 expression after memory formation limits memory linking, impacting memory recall and aging.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Immunology

Background:

  • Real-world memories are context-dependent and temporally organized.
  • The brain's mechanism for segregating temporally distinct events is not fully understood.
  • Time intervals influence the association and recall of sequential memories.

Purpose of the Study:

  • To investigate the role of C-C chemokine receptor type 5 (CCR5) in temporal memory linking.
  • To elucidate the molecular mechanisms underlying the segregation of memories over time.
  • To explore the implications of CCR5 in age-related memory impairments.

Main Methods:

  • Investigated delayed CCR5 expression in mouse dorsal CA1 neurons post-memory formation.
  • Assessed neuronal excitability and memory ensemble overlap.
  • Utilized Ccr5 knockout mice and CCR5-inhibiting drugs in aged mice.

Main Results:

  • Delayed CCR5 expression (12-24h) after memory formation decreases neuronal excitability in dorsal CA1 neurons.
  • Reduced neuronal excitability leads to decreased overlap between memory ensembles, closing the temporal window for memory linking.
  • Age-related increases in CCR5 and CCL5 impair memory linking, which is reversible via Ccr5 knockout or FDA-approved drug treatment.

Conclusions:

  • CCR5 plays a critical role in regulating the temporal window for linking memories.
  • Targeting CCR5 offers potential therapeutic strategies for age-related memory linking deficits.
  • Findings provide molecular insights into temporal memory organization and its age-related decline.