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DNA base modification: ionized base pairs and mutagenesis.

L C Sowers, B R Shaw, M L Veigl

    Mutation Research
    |April 1, 1987
    PubMed
    Summary
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    Hydrogen bonding in DNA can involve ionized bases, especially modified ones, impacting DNA stability and structure. Understanding these ionized base pairs is crucial for studying DNA mutations and reactivity.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Structural Biology

    Background:

    • Hydrogen bonding is fundamental to DNA structure and function.
    • Modified bases can alter normal base-pairing interactions.
    • The role of ionized forms in DNA base pairing requires further investigation.

    Purpose of the Study:

    • To re-examine hydrogen bonding in normal and modified DNA bases.
    • To investigate the contribution of ionized base pairs to DNA stability.
    • To explore the implications of ionized bases on DNA structure and reactivity.

    Main Methods:

    • Review of physical evidence for ionized base pairs.
    • Analysis of thermodynamic data in aqueous solution under physiological conditions.
    • Consideration of tautomeric, ionized, and conformational (syn, anti, wobble) forms.

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    Main Results:

    • Physical evidence supports the existence of ionized base pairs.
    • Base ionization significantly contributes to the stability of modified base pairs.
    • Ionized bases can alter DNA structure and affect chemical reactivity.

    Conclusions:

    • Ionized base pairs play a substantial role in the stability of modified DNA bases.
    • The presence of ionized bases has implications for DNA structure and function.
    • This model is valuable for DNA-sequence analysis in mutagenesis studies.