Ag Functionalized In₂O₃ Derived From MIL-68(In) as an Efficient Electrochemical Glucose Sensor

Area of Science:

• Materials Science
• Electrochemistry
• Nanotechnology

Background:

• Development of efficient non-enzymatic glucose sensors is crucial for diagnostics.
• Metal-organic frameworks (MOFs) offer tunable properties for material synthesis.
• Nickel foam (NF) provides a high surface area substrate for electrode modification.

Purpose of the Study:

• To synthesize and characterize Ag@In2O3 nanoparticles on nickel foam for glucose sensing.
• To evaluate the electrochemical performance of the modified electrode as a non-enzymatic glucose sensor.
• To investigate the selectivity and sensitivity of the sensor towards glucose detection.

Main Methods:

• Solvothermal synthesis of MIL-68(In) MOF.
• Ag+ ion entrapment and subsequent calcination to form Ag@In2O3.
• Modification of nickel foam with Ag@In2O3 for electrochemical sensing.
• Amperometric detection of glucose in an alkaline medium.

Main Results:

• Ag@In2O3/NF exhibited two linear detection ranges for glucose: 10 μM to 0.8 mM and 0.8 mM to 2.16 mM.
• Achieved high sensitivity of 3.31 mA mM⁻¹ cm⁻² and 1.51 mA mM⁻¹ cm⁻² in the respective ranges.
• Demonstrated a low detection limit of 0.49 µM and excellent selectivity against interfering substances.

Conclusions:

• The Ag@In2O3/NF composite is a promising material for non-enzymatic glucose sensing.
• The developed sensor offers high sensitivity, selectivity, and a low detection limit.
• This approach provides a viable pathway for developing advanced electrochemical biosensors.