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The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Updated: Sep 22, 2025

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

Published on: December 28, 2011

Single-Cell Analysis Reveals Transcriptomic Reprogramming in Aging Cardiovascular Endothelial Cells.

Bo Gou^1,2,3,4, Xiaojing Chu^1,2,3, Yi Xiao^1,2,3,4

¹State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Frontiers in Cardiovascular Medicine

|May 26, 2022

Summary

This summary is machine-generated.

Cardiovascular endothelial cell aging involves changes in gene expression related to ribosome biogenesis, inflammation, and apoptosis. The study identifies Jun as a key factor in this process, offering potential therapeutic targets for cardiovascular diseases.

Keywords:

age-dependent genes cardiovascular endothelial cells scRNA-seq senescence transcriptomic reprogramming

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Assessing Cardiac Reprogramming using High Content Imaging Analysis

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Last Updated: Sep 22, 2025

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

Published on: December 28, 2011

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

Assessing Cardiac Reprogramming using High Content Imaging Analysis

Assessing Cardiac Reprogramming using High Content Imaging Analysis

Published on: October 26, 2020

Area of Science:

Cardiovascular Biology
Cellular Aging
Molecular Genetics

Background:

Cardiovascular endothelial cell (EC) senescence is a critical factor in age-related cardiovascular diseases.
The molecular mechanisms underlying cardiovascular EC aging remain largely unexplored.

Purpose of the Study:

To characterize the transcriptomic changes in cardiovascular ECs during aging.
To identify key molecular players and pathways involved in cardiovascular aging.

Main Methods:

Transcriptomic profiling of cardiovascular ECs across different ages.
Analysis of gene expression patterns, pathway enrichment, and transcriptional regulatory networks.
Validation of candidate genes using in vitro and in vivo models.

Main Results:

Aging significantly alters gene expression in cardiovascular ECs, impacting ribosome biogenesis, inflammation, apoptosis, and angiogenesis.
Collagen genes play a role in cell-cell crosstalk during cardiovascular aging.
Jun was identified as a key transcription factor upregulated in aged cardiovascular ECs.

Conclusions:

Transcriptomic reprogramming occurs in aging murine cardiovascular ECs.
Jun is implicated in cardiovascular senescence.
The findings provide insights into molecular mechanisms of cardiovascular aging and potential therapeutic targets.