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Published on: December 9, 2015
Correlation Between Tic Disorders and Serum 25-Hydroxyvitamin D Levels in Chinese Children
Simei Wang1, Quanmei Xu1, Anqi Wang1
1Department of Neurology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Insights
Serum 25-hydroxyvitamin D deficiency is linked to tic disorders (TDs) in Chinese children. This deficiency was not associated with TD severity but was more prevalent in children over 9 years old.
Area of Science:
- Pediatric Neurology
- Nutritional Science
- Epidemiology
Background:
- Tic disorders (TDs) are common in childhood.
- Vitamin D deficiency is a growing global health concern.
- The relationship between vitamin D status and TDs requires further investigation.
Purpose of the Study:
- To investigate the association between serum 25-hydroxyvitamin D levels and the presence of tic disorders in Chinese children.
- To compare vitamin D levels and deficiency rates between children with TDs and healthy controls.
Main Methods:
- A cross-sectional study involving 2960 children with TD and 2665 healthy controls (aged 5-14 years).
- Measurement of serum 25-hydroxyvitamin D levels.
- Comparison of vitamin D status and deficiency prevalence between groups, with age-stratified analysis.
Main Results:
- Children with TD exhibited significantly lower mean serum 25-hydroxyvitamin D levels compared to controls (P < 0.001).
- A higher proportion of children with TD had vitamin D deficiency.
- No correlation was found between vitamin D deficiency and TD severity.
- Vitamin D deficiency was most pronounced in TD patients over 9 years of age.
Conclusions:
- Serum 25-hydroxyvitamin D deficiency is correlated with tic disorders in Chinese children.
- The severity of TD is not associated with vitamin D deficiency.
- Age is a factor, with a notable increase in vitamin D deficiency among children over 9 years old with TD.
Objective:
To explore the correlation between serum 25-hydroxyvitamin D levels and tic disorders (TDs) in Chinese children.
Methods:
We selected 2960 children with TD and 2665 healthy controls, aged 5-14 years, from the Department of Neurology of the Shanghai Children's Hospital. Serum 25-hydroxyvitamin D levels and degrees of vitamin D deficiency were compared between patients with TD and healthy children.
Results:
The mean serum 25-hydroxyvitamin D level in the TD group was significantly lower than that in the control group (P < 0.001). The proportion of patients with 25-hydroxyvitamin D deficiency in the TD group was significantly higher than that in the control group. However, there was no correlation between 25-hydroxyvitamin D deficiency and the severity of TD. In addition, for age-wise comparison, mean levels of 25-hydroxyvitamin D and its deficiency in the TD group were the most significant in children over 9 years of age.
Conclusion:
There is a correlation between 25-hydroxyvitamin D deficiency and TD in Chinese children, but not between 25-hydroxyvitamin D deficiency and the severity of TD. There was a correlation between age and deficiency of 25-hydroxyvitamin D; this deficiency was most pronounced among those over the age of 9 years.
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