Related Experiment Video

Updated: Jun 22, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

16.2K

Thrombotic microangiopathies: An illustrated review

Mouhamed Yazan Abou-Ismail1, Sargam Kapoor2, Divyaswathi Citla Sridhar3

  • 1Division of Hematology and Hematologic Malignancies Department of Internal Medicine University of Utah Health Sciences Center Salt Lake City Utah USA.

Research and Practice in Thrombosis and Haemostasis
|May 26, 2022
PubMed

Insights

Thrombotic microangiopathies (TMAs) are serious blood disorders. This review details their diagnosis and management, including emerging therapies for complement-mediated TMAs.

Area of Science:

  • Hematology
  • Pathophysiology
  • Rare Diseases

Background:

  • Thrombotic microangiopathies (TMAs) encompass diverse disorders causing thrombosis.
  • TMAs present with microangiopathic hemolytic anemia, thrombocytopenia, and organ ischemia.
  • These conditions carry significant morbidity and mortality, with evolving management strategies.

Purpose of the Study:

  • To review the incidence, pathophysiology, diagnosis, and management of key TMAs.
  • To focus on thrombotic thrombocytopenic purpura (TTP), Shiga toxin-associated HUS, and complement-mediated HUS.
  • To highlight novel complement-directed therapies for TMAs.

Main Methods:

  • Illustrated review of TMAs.
  • Focus on specific TMA subtypes: TTP, STX-HUS, c-HUS, HCT-TMA, drug-induced TMA.
  • Discussion of diagnostic evaluations and therapeutic approaches.

Main Results:

  • Detailed descriptions of the incidence, pathophysiology, diagnosis, and management of selected TMAs.
  • Identification of emerging complement-directed therapies for complement-mediated TMAs.
  • Emphasis on the importance of accurate diagnosis for effective management.

Conclusions:

  • Accurate diagnosis is crucial for managing heterogeneous TMAs.
  • Management strategies for TMAs are continually evolving.
  • Emerging therapies show promise for specific TMA subsets, particularly complement-mediated forms.
Keywords:
atypical hemolytic uremic syndromehemolytic uremic syndromemanagementpathophysiologythrombotic microangiopathiesthrombotic thrombocytopenic purpura

More Related Videos

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.1K
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

2.9K

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...