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Updated: Sep 22, 2025

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
Published on: June 7, 2015
Formulation, optimization and validation of floating oral in situ gel of Ivabradine hydrochloride
Dattatray Desai1, Rajashree Masareddy1, Archana Patil1
1Department of Pharmaceutics, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education & Research, Belagavi, Karnataka, 590010, India.
Abstract:
Aim: Ivabradine hydrochloride is a hyperpolarized activated channel blocker used for symptomatic treatment of chronic angina pectoris. However, due to its short half-life it is rapidly eliminated from systemic circulation. Materials & methods: Floating in situ gel was formulated using sodium alginate and HPMC K 100 M by pH induced ion gelation technique employing 32 factorial design for optimization and evaluated. Results: The in situ formulation remained buoyant in gastric environment for 12 h. Optimized formulation sustained and prolonged drug release in comparison with marketed product. Kinetic analysis of drug release indicated non fickian mechanism. Short term stability studies showed no significant changes indicating good formulation stability. Conclusion: Formulated in situ solution shows potential effective sustained release over a prolonged period of time.
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