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Related Experiment Video

Updated: Sep 22, 2025

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices.

Xiaobing Zheng¹, Yunfan Pan¹, Yuan Zhang²

¹State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|May 26, 2022

Summary

A novel interventional sonothrombolysis (IST) method effectively dissolves left ventricular assist device (LVAD) thrombosis. This ultrasound-based treatment using drug-loaded microbubbles offers a safer and more efficient solution for LVAD patients.

Keywords:

LVAD interventional therapy microbubble thrombolysis ultrasound

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Last Updated: Sep 22, 2025

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Published on: June 12, 2021

Area of Science:

Biomedical Engineering
Cardiovascular Research
Interventional Cardiology

Background:

Left ventricular assist device (LVAD) implantation is crucial for heart failure treatment.
LVAD thrombosis affects 4-9% of patients annually, posing a significant mortality risk.
Existing thrombolysis methods for LVADs lack efficiency and safety.

Purpose of the Study:

To develop and evaluate an interventional sonothrombolysis (IST) method for LVAD thrombosis.
To assess the efficacy and safety of IST in a preclinical model.

Main Methods:

Installation of ultrasound transducer rings on the LVAD shell.
Interventional injection of drug-loaded, thrombus-targeted microbubbles into the LVAD.
Ultrasound-induced microbubble cavitation to deliver thrombolytic drugs to the thrombus.

Main Results:

Successful dissolution of LVAD thrombus within 30 minutes in a live sheep model.
No observed damage to the LVAD or surrounding organs.
Demonstrated superior efficiency and safety compared to existing thrombolysis techniques.

Conclusions:

Interventional sonothrombolysis (IST) presents a promising, minimally invasive approach for managing LVAD thrombosis.
This technique offers a potentially life-saving advancement for heart failure patients with LVADs.
Further clinical investigation is warranted to validate IST's efficacy and safety in human patients.