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Recent advances in anti-multidrug resistance for nano-drug delivery system

Changduo Wang1, Fashun Li1, Tianao Zhang1

  • 1Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, China.

Drug Delivery
|May 26, 2022
PubMed

Insights

Nano-drug delivery systems (NDDS) offer a promising strategy to overcome chemotherapy drug resistance in tumors. These systems sensitize anticancer drugs and reduce side effects, improving treatment efficacy.

Area of Science:

  • Oncology
  • Nanotechnology
  • Pharmacology

Background:

  • Chemotherapy resistance is a primary cause of cancer treatment failure.
  • Increased drug doses enhance efficacy but are limited by toxicity.
  • Multidrug resistance (MDR) necessitates novel therapeutic strategies.

Purpose of the Study:

  • To review the causes of multidrug resistance (MDR) in tumors.
  • To explore recent advances in nano-drug delivery systems (NDDS) for overcoming MDR.
  • To summarize the mechanisms by which NDDS sensitize anticancer drugs.

Main Methods:

  • Literature search on nano-drug delivery systems (NDDS) and multidrug resistance (MDR).
  • Analysis of NDDS mechanisms in combating drug-resistant tumors.
  • Review of studies on sensitizing chemotherapeutic drugs using NDDS.

Main Results:

  • NDDS can overcome MDR through various mechanisms.
  • Mechanisms include bypassing drug efflux, controlled drug release, and metabolic interference.
  • NDDS demonstrate potential in reducing chemotherapy side effects.

Conclusions:

  • NDDS represent a viable approach to combatting multidrug resistance in cancer therapy.
  • The efficacy of NDDS is attributed to multiple underlying mechanisms.
  • Further research and development in NDDS hold significant promise for future cancer treatment.
Keywords:
Multidrug resistancenano-drug delivery systemnanoparticles

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