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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

677
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Related Experiment Video

Updated: Sep 22, 2025

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Boosting Anti-tumour Immunity Using Adjuvant Apigenin.

Jun Huang1, Xuedong Chen1, Zaoshang Chang1

  • 1College of Basic Medicine, Shaoyang University, Shaoyang 422000, China.

Anti-Cancer Agents in Medicinal Chemistry
|May 26, 2022
PubMed
Summary

Apigenin, a natural flavone, can enhance anti-tumour immunity by modulating immune cells within the tumour microenvironment. This may improve the effectiveness of cancer therapies like immunotherapy.

Keywords:
Apigeninanti-tumour immunitycytotoxic CD8+ T Lymphocytes (CTLs)natural killer (NK) cellstumour microenvironment (TME)

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Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Tumour microenvironment (TME) interactions and secretions critically influence tumour growth and therapeutic responses.
  • Immunosuppressive cells (Tregs, MDSCs, TAMs, CAFs) within the TME can exhaust anti-tumour immunity.
  • Stimulating anti-tumour immunity requires suppressing immunosuppressive cells and activating cytotoxic lymphocytes (NK cells, CD8+ T cells).

Approach:

  • This review examines the anticancer properties of apigenin, a natural flavone.
  • We explore how apigenin interacts with various cells in the TME.
  • The focus is on apigenin's potential to modulate immune responses within the tumour.

Key Points:

  • Apigenin exhibits anticancer properties by influencing cancer cell death pathways.
  • It can stimulate anti-tumour immune cells to release cytotoxic signals.
  • Apigenin suppresses the release of tumour-promoting molecules from immunosuppressive cells.

Conclusions:

  • Apigenin's interactions within the TME can bolster anti-tumour immunity.
  • Modulating the TME with apigenin may enhance the efficacy of cancer treatments.
  • Apigenin shows promise for improving immunotherapy outcomes by reprogramming the tumour microenvironment.