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Empty sella associated with inappropriate TSH secretion.

W H Hoffman, B G England, L M Gomez

    Neuropediatrics
    |February 1, 1987
    PubMed
    Summary
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    A child with autoimmune thyroid disease developed pseudotumor cerebri and empty sella after thyroid therapy. This suggests a link between these conditions and abnormal pituitary function.

    Area of Science:

    • Endocrinology
    • Neurology
    • Pediatrics

    Background:

    • Primary hypothyroidism is a common endocrine disorder.
    • Pseudotumor cerebri (idiopathic intracranial hypertension) can occur secondary to various conditions.
    • Thyroid hormone replacement therapy is standard for hypothyroidism.

    Observation:

    • A 10-year-old child with long-standing primary hypothyroidism presented with pseudotumor cerebri after initiating thyroid therapy.
    • The patient subsequently developed an empty sella and inappropriate thyrotropin secretion.
    • No other endocrine abnormalities or signs of thyroid hormone resistance were identified.

    Findings:

    • The case highlights a potential association between autoimmune thyroid disease, pseudotumor cerebri, and empty sella.

    Related Experiment Videos

  • Inappropriate thyrotropin secretion was observed, suggesting pituitary dysfunction.
  • The findings support a link between these specific clinical manifestations.

    • Implications:

    • This case reinforces the association between autoimmune thyroid disease and neurological complications like pseudotumor cerebri.
    • It suggests a potential mechanism involving the pituitary gland in patients with autoimmune thyroid disease and related conditions.
    • Further research may elucidate the underlying pathophysiology connecting autoimmune thyroid disease, pituitary dysfunction, and intracranial pressure abnormalities.