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Receptor binding of corticosterone in some rat brain structures following neonatal blockade of the hypophyseoadrenal
Neuroscience and Behavioral Physiology
|September 1, 1986
Abstract:
Administration of hydrocortisone to rats during the first five postnatal days leads to the blockade of the hypophyseoadrenal system and results in a decrease in the number of corticosterone receptors in the hypophysis, hypothalamus, and hippocampus. Such a decrease in the receptor binding of corticosterone in the brain structures involved in the regulation of the hypophyseoadrenal system by a feedback mechanism is due to a change in the number of true glucocorticoid receptors.