Related Experiment Video

Updated: Sep 22, 2025

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.5K

Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis

Tafadzwa Dzinamarira1, Grant Murewanhema2, Itai Chitungo3

  • 1School of Health Systems & Public Health, University of Pretoria, Pretoria 0002, South Africa; ICAP at Columbia University, Harare, Zimbabwe.

Journal of Infection and Public Health
|May 26, 2022
PubMed

Insights

This study found no increased COVID-19 mortality risk for individuals with HIV. Current findings contribute to the ongoing debate regarding the connection between HIV infection and COVID-19 outcomes.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Epidemiology

Background:

  • The interplay between Human Immunodeficiency Virus (HIV) infection and Coronavirus Disease 2019 (COVID-19) clinical outcomes is a critical public health concern.
  • This systematic review and meta-analysis aimed to elucidate the association between HIV comorbidity and COVID-19 mortality rates.

Approach:

  • A comprehensive literature search was conducted across PubMed, Google Scholar, and WHO databases from December 1-7, 2021.
  • Data extraction and screening followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
  • Relative risk of mortality was calculated using a random-effects model, with study quality assessed by GRADE and bias by Egger's test.

Key Points:

  • Analysis of 16 studies revealed a COVID-19 mortality rate of 7.97% in patients with HIV (4,287/53,801) versus 0.69% in those without HIV (127,961/18,513,747).
  • The random-effects model indicated no statistically significant increase in mortality risk for COVID-19 patients with HIV (Relative Risk: 1.07, 95% Confidence Interval: 0.86-1.32).
  • Substantial heterogeneity (I² = 91%) was observed across studies, but publication bias was not significant.

Conclusions:

  • The findings do not establish a link between HIV infection and an elevated risk of COVID-19 mortality.
  • This research contributes to the existing body of conflicting evidence on the relationship between HIV and COVID-19 outcomes.
Abstract

Keywords:
AIDSCOVID-19HIVMeta-analysisMortalitySystematic review

More Related Videos

Isolation, Transfection, and Culture of Primary Human Monocytes09:13

Isolation, Transfection, and Culture of Primary Human Monocytes

Published on: December 16, 2019

13.7K
An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection08:14

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

10.4K

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
376
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
713
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
430
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
47.0K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
335