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Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

56
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
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Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

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Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
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Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
49

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Related Experiment Video

Updated: Sep 22, 2025

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

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Short-Term Left Ventricular Reverse Remodeling after Transcatheter Aortic Valve Replacement in Children.

Spencer B Barfuss1, Dana M Boucek1, Carol A McFarland1

  • 1Division of Cardiology, Department of Pediatrics, University of Utah and Primary Children's Hospital, Salt Lake City, Utah.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|May 26, 2022
PubMed
Summary

Transcatheter aortic valve replacement (TAVR) in children shows significant left ventricular (LV) reverse remodeling at six months. This suggests TAVR may be a viable alternative to surgical aortic valve replacement for pediatric patients.

Keywords:
Congenital heart diseaseLV remodelingLeft bundle branch blockReverse remodelingTAVR

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Area of Science:

  • Pediatric cardiology
  • Cardiovascular imaging
  • Interventional cardiology

Background:

  • Limited data exists on left ventricular (LV) reverse remodeling post-transcatheter aortic valve replacement (TAVR) in pediatric populations.
  • Assessing LV reverse remodeling is crucial for understanding long-term outcomes in children undergoing TAVR.

Purpose of the Study:

  • To evaluate changes in LV echocardiographic parameters six months after TAVR in pediatric patients.
  • To identify factors associated with successful or failed reverse remodeling.

Main Methods:

  • Retrospective analysis of 22 pediatric patients (<21 years) who underwent TAVR.
  • Collection of preprocedural and 6-month echocardiographic data including LV volume, mass, dimensions, ejection fraction (EF), sphericity, and strain.
  • Definition of failure to reverse remodel based on specific echocardiographic criteria.

Main Results:

  • Significant improvements were observed in LV volume, mass, dimensions, and sphericity index at 6 months post-TAVR.
  • Ejection fraction (EF) and longitudinal strain remained normal at baseline and follow-up.
  • Three patients (14%) failed to demonstrate reverse remodeling, with two experiencing left bundle branch block.

Conclusions:

  • Pediatric patients undergoing TAVR exhibit substantial LV reverse remodeling at six months.
  • TAVR presents a potential alternative to surgical aortic valve replacement in children.
  • Further research is needed to optimize TAVR timing and investigate the impact of left bundle branch block on outcomes.