RNAPII driven post-translational modifications of nucleosomal histones
Justin Chan1, Amarjeet Kumar1, Hidetoshi Kono1
1Molecular Modelling and Simulation (MMS) Team, Institute for Quantum Life Science (iQLS), National Institutes for Quantum Science and Technology (QST), 8-1-7 Umemidai, Kizugawa, Kyoto 619-0215, Japan.
Trends in Genetics : TIG
|May 26, 2022
Summary
RNA polymerase II (RNAPII) transcription rate dictates histone post-translational modification (PTM) patterns. RNAPII
Area of Science:
- Molecular Biology
- Epigenetics
- Chromatin Biology
Background:
- Histone post-translational modifications (PTMs) are crucial for gene regulation.
- The precise mechanisms establishing PTM distributions on chromatin are not fully understood.
Purpose of the Study:
- To review the role of RNA polymerase II (RNAPII) in regulating histone PTMs.
- To elucidate how RNAPII transcription rates influence H2BK120/K123 ubiquitination and H3K4/K36 methylation.
Main Methods:
- Review of existing literature on RNAPII transcription and histone modifications.
- Analysis of mechanisms linking RNAPII elongation and recruitment rates to PTM establishment.
Main Results:
- RNAPII transcription rate is determined by elongation and recruitment rates.
- Two mechanisms link RNAPII transcription rate to PTM distribution: RNAPII C-terminal domain phosphorylation (Ser2P/Ser5P) and enzyme catalytic cycles.
- RNAPII phosphorylation patterns recruit histone PTM enzymes, influencing PTM location, while enzyme catalysis determines methylation states.
Conclusions:
- RNAPII transcription rate is a key determinant of both the location and state of histone methylations.
- Understanding these mechanisms provides insight into epigenetic regulation and gene expression.
Keywords:
RNAPIImethylationphosphorylationpost-translational modificationtranscription rateubiquitinationMore Related Videos
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