Subcortical pathways involved in the mediation of adrenocortical responses following frontal cortex stimulation

The purpose of this study was to identify the subcortical neural pathways which mediate adrenocortical responses following cortical stimulation. The frontal cortex was stimulated in intact rats and in animals with medial or lateral septal or preoptic lesions or with large or small anterior hypothalamic deafferentations. All the above-mentioned lesions have significantly blocked the adrenocortical responses following frontal cortex stimulation, suggesting that the above-mentioned subcortical structures are involved in the mediation of this response.