Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Sep 21, 2025

Chronic Salmonella Infected Mouse Model
09:01

Chronic Salmonella Infected Mouse Model

Published on: May 31, 2010

17.5K

Mouse Model to Study Salmonella-Induced Colitis.

Katrin Ehrhardt1, Guntram A Grassl2

  • 1Institute of Medical Microbiology and Hospital Epidemiology and German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover Medical School, Hannover, Germany.

Methods in Molecular Biology (Clifton, N.J.)
|May 26, 2022
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Argyrin B exhibits potent therapeutic efficacy in a Clostridioides difficile-infection mouse model while preserving microbiota functionality.

npj antimicrobials and resistance·2026
Same author

Culture-specific transcriptional drifts limit the fidelity of organoid infection models.

PLoS pathogens·2026
Same author

Host genetics shapes the recovery of the gut microbiome after antibiotic treatment: the role of the blood group related <i>B4galnt2</i> gene.

mSystems·2026
Same author

An exhaustive cell-based screen coupled with an intracellular-induced lux-based reporter identified bioactive molecules that inhibit host cell infection by intracellular pathogens.

Frontiers in cellular and infection microbiology·2026
Same author

Therapeutic antibody delivery: vector tools to boost efficacy and affordability.

Frontiers in immunology·2026
Same author

The extent of monocytic myeloid suppressor cells induction determines the host immune response during Mycobacterium avium infection.

Microbes and infection·2025

This study explores Salmonella infection in mice, using an antibiotic-treated model to overcome gut microbiota resistance. This approach aids in understanding Salmonella-induced colitis and host-pathogen interactions.

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Salmonella colonizes the mouse cecum and colon, inducing inflammation and colitis.
  • Studying non-typhoidal Salmonella enterica serovars requires overcoming intestinal colonization resistance.
  • Reducing gut microbiota with antibiotics prior to infection facilitates Salmonella studies.

Purpose of the Study:

  • To establish and utilize an in vivo mouse model for studying Salmonella intestinal infections.
  • To investigate the role of mucosal host defenses in Salmonella-induced colitis.
  • To identify host and bacterial factors influencing acute infections and persistence.

Main Methods:

  • Oral antibiotic treatment to reduce gut microbiota in mice.
  • Infection with non-typhoidal Salmonella enterica serovars.
Keywords:
ColitisInfectionInflammationIntestinePathologySalmonella

More Related Videos

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.3K
Murine Colitis Modeling using Dextran Sulfate Sodium DSS
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Published on: January 19, 2010

50.3K

Related Experiment Videos

Last Updated: Sep 21, 2025

Chronic Salmonella Infected Mouse Model
09:01

Chronic Salmonella Infected Mouse Model

Published on: May 31, 2010

17.5K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.3K
Murine Colitis Modeling using Dextran Sulfate Sodium DSS
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Published on: January 19, 2010

50.3K
  • Analysis of histopathological changes and host-pathogen interactions.

    • Main Results:

    • The antibiotic-induced reduction of gut microbiota successfully overcomes colonization resistance.
    • The model allows for the study of inflammation and colitis induced by Salmonella.
    • Facilitates identification of factors contributing to Salmonella infection outcomes.

    Conclusions:

    • The in vivo colitis model is essential for understanding Salmonella intestinal pathogenesis.
    • This model is crucial for analyzing host defenses and bacterial factors in Salmonella infections.
    • It aids in identifying mechanisms of acute infection and bacterial persistence.