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HNF1A-AS1: A Tumor-associated Long Non-coding RNA
Yuling Liu1,2, Fangnan Zhao1,2, Fangshun Tan1,2
1Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
Current Pharmaceutical Design
|May 27, 2022
Summary
Hepatocyte nuclear factor 1 homeobox A antisense RNA 1 (HNF1A-AS1), a long non-coding RNA, is implicated in various cancers. Its dysregulation impacts tumor growth, making it a potential biomarker and therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Hepatocyte nuclear factor 1 homeobox A antisense RNA 1 (HNF1A-AS1) is a long non-coding RNA (lncRNA).
- HNF1A-AS1 plays a role in the development of various tumors.
- It is considered a potential novel biomarker for cancer.
Purpose of the Study:
- To review the biological effects of HNF1A-AS1 in different tumor types.
- To elucidate the specific molecular mechanisms underlying HNF1A-AS1's role in tumorigenesis.
- To assess the clinical significance of HNF1A-AS1 as a biomarker.
Main Methods:
- Literature review and analysis of existing research.
- Summarizing studies on HNF1A-AS1's association with various cancers.
- Investigating the molecular mechanisms, including microRNA targeting and EMT regulation.
Main Results:
- HNF1A-AS1 expression is frequently upregulated in cancers like liver, breast, lung, and colon cancer.
- Downregulation of HNF1A-AS1 is observed in specific neoplasms, including gastroenteropancreatic neuroendocrine neoplasms.
- HNF1A-AS1 influences tumor proliferation, invasion, migration, and apoptosis, partly through targeting miR-661 and miR-124, and regulating epithelial-mesenchymal transition (EMT).
Conclusions:
- LncRNA HNF1A-AS1 is significantly associated with the development of numerous cancers.
- HNF1A-AS1 regulates tumor growth via diverse molecular pathways.
- HNF1A-AS1 holds promise as a novel biomarker and therapeutic target for multiple cancer types.
Keywords:
HNF1A-AS1Molecular mechanismadenocarcinomalong non-coding RNAneuroendocrine neoplasmstherapeutic targetMore Related Videos
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