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Updated: Sep 21, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks
Published on: March 17, 2023
Bottlebrush-Colloid Janus Nanoparticles
Jingyun Jing1,2, Bingyin Jiang1, Fuxin Liang1,3
1State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Abstract:
A bottlebrush-colloid Janus nanoparticle (JNP) with a ball-and-stick structure is reported. A single poly(4-vinyl benzyl chloride) (PVBC) polymer chain was grafted onto the amine-capped Fe3O4@NH2 nanoparticle. pH-responsive 2-diethylaminoethyl methacrylate (DEAEMA) and water-soluble oligo(ethylene glycol) methacrylate (OEGMA) were sequentially grown from the PVBC backbone by ATRP, forming a core-shell bottlebrush. The synthesized PVBC208-g-(PDEAEMA13-b-POEGMA8)-Fe3O4@NH2 JNPs are dispersible in water and can be manipulated by a magnet. The Fe3O4 NPs with exposed -NH2 groups facilitate accumulation at acidic sites. Hydrophobic dyes can be loaded within the PDEAEMA at pH ≥ 7.5, while they are released at pH values below 6.8. The composite JNPs are promising as a guided pH-responsive delivery vector toward acidic solid tumors.
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