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Helicobacter pylori infection in pediatrics with gastrointestinal complaints
Peiman Nasri1,2, Hossein Saneian1,2, Fatemeh Famouri1,2
1Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences Isfahan, Iran.
Insights
The prevalence of Helicobacter pylori infection in children with gastrointestinal issues is low, with only 7.8% testing positive. This finding questions the commonly believed high rates of this infection in pediatric populations.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Microbiology
Background:
- Helicobacter pylori is a significant pathogen affecting gastric mucosa in both adults and children.
- Understanding its prevalence in pediatric populations with gastrointestinal symptoms is crucial for accurate diagnosis and treatment.
Purpose of the Study:
- To determine the prevalence of Helicobacter pylori infection in pediatric patients presenting with gastrointestinal complaints.
- To explore the correlation between H. pylori infection and specific gastrointestinal symptoms in children.
Main Methods:
- A cross-sectional study was conducted on 400 pediatric patients undergoing endoscopic biopsy.
- Data collected included patient demographics, gastrointestinal complaints, and H. pylori infection status from pathology reports.
Main Results:
- Helicobacter pylori infection was detected in 7.8% of the pediatric cases.
- Prevalence was higher in boys (10.7%) than girls (4.6%) and increased with age.
- No significant association was found between H. pylori infection and the type of gastrointestinal complaint.
Conclusions:
- The study indicates a lower-than-expected prevalence of H. pylori infection among pediatric patients with gastrointestinal symptoms.
- These findings may necessitate a re-evaluation of the perceived high rates and clinical significance of H. pylori in children.
Background:
Helicobacter pylori is one of the most important pathogenic bacteria in gastric mucosa both in adults and pediatrics. Here we aimed to investigate the prevalence of Helicobacter pylori in pediatrics with gastrointestinal complaints by the endoscopic method and using pathology reports.
Methods:
This is a cross-sectional study that was performed in 2019-2020 in Imam Hossein hospital affiliated to Isfahan University of Medical Sciences on medical documents of pediatrics that underwent gastric or duodenal biopsy via endoscopy. We collected data regarding patients' age, gender, place of residence, type of gastrointestinal complaints, and prevalence of Helicobacter pylori infection from the medical reports. We also investigated the possible correlation between the presence of Helicobacter pylori and the type of complaints among patients.
Results:
A total number of 400 pediatrics entered the study. Abdominal pain was the most common complaint (42%). Helicobacter pylori infection was found in 31 cases (7.8%). The prevalence of Helicobacter pylori infection in boys (10.7%) was significantly higher than in girls (4.6%) (P = 0.02) and was significantly related to the age group of children (P<0.001) in the way that Helicobacter pylori infection was more common in higher ages. There was no significant relationship between the prevalence of Helicobacter pylori infection and the type of complaint (P = 0.29).
Conclusion:
We showed that the prevalence of Helicobacter pylori infection is low among pediatrics with gastrointestinal complaints and this issue could cast doubt on the high prevalence rates and importance of this infection in children.
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