Estimated change of COVID-19 vaccine efficacy due to omicron variant SARS CoV2

COVID-19, an infection caused by SARS CoV2, is a worldwide public health problem at present. Pandemic of this respiratory viral infection has occurred since 2020. Recently, in late 2021, the new variant of SARS CoV2, omicron, was reported from Africa and already cause problems in many countries. Regarding omicron variant, there are many mutations within the molecule of SARS CoV2. The effect of molecular change is unknown and the study on its clinical impact is interesting. An important possible clinical impact of the mutation in omicron is a change of COVID-19 vaccine efficacy. Herein, we used a clinical mathematical model to assess the effect of mutations in omicron variants on vaccine efficacy. Compared to classical SARS CoV2, the omicron form has a large estimated decrease, believed to be roughly 12 times normal. Therefore, it is necessary to find out a new effective vaccine for controlling of the new omicron variant.