Related Experiment Video

Updated: Sep 21, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

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DNMT3A and DNMT3B in Breast Tumorigenesis and Potential Therapy

Xiaxia Man1, Qi Li2, Baogang Wang3

  • 1Department of Oncologic Gynecology, the First Hospital of Jilin University, Jilin, China.

Frontiers in Cell and Developmental Biology
|May 27, 2022
PubMed

Insights

DNA methyltransferases (DNMT3A and DNMT3B) are crucial in breast cancer development. Targeting these enzymes offers a promising therapeutic strategy for breast cancer treatment.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Breast cancer is a major cause of cancer deaths in women globally.
  • DNA methylation, regulated by DNA methyltransferases (DNMTs), is vital in breast cancer progression.
  • While DNMT1's role is known, DNMT3A and DNMT3B roles require further review.

Purpose of the Study:

  • To review the roles of DNMT3A and DNMT3B in breast tumorigenesis and development.
  • To discuss single nucleotide polymorphisms (SNPs) and mutations of DNMT3A and DNMT3B in breast cancer.
  • To summarize regulatory mechanisms of DNMT3A and DNMT3B by non-coding RNAs and signaling pathways.

Main Methods:

  • Literature review of existing studies on DNMT3A and DNMT3B in breast cancer.
  • Analysis of data regarding SNPs and mutations.
  • Synthesis of information on regulatory pathways and therapeutic targeting.

Main Results:

  • DNMT3A and DNMT3B are implicated in breast cancer initiation and progression.
  • SNPs and mutations in DNMT3A and DNMT3B are associated with breast cancer.
  • Non-coding RNAs and signaling pathways significantly regulate DNMT3A and DNMT3B expression.

Conclusions:

  • DNMT3A and DNMT3B are critical players in breast cancer.
  • Understanding their regulation provides insights into molecular mechanisms.
  • Targeting DNMT3A and DNMT3B presents a potential therapeutic avenue for breast cancer.
Keywords:
DNMT3BDnmt3abreast cancerinhibitorsmethylation

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