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Design Principles of the Rotary Type 9 Secretion System
Abhishek Trivedi1,2,3, Jitendrapuri Gosai1,2,3, Daisuke Nakane4
1School of Life Sciences, Arizona State University, Tempe, AZ, United States.
Frontiers in Microbiology
|May 27, 2022
Summary
The bacterial type 9 secretion system (T9SS) is a proton-driven rotary motor essential for bacterial gliding motility. This review details T9SS mechanics, its role in bacterial swarming, and knowledge gaps in its machinery.
Area of Science:
- Microbiology
- Molecular Biology
- Biophysics
Background:
- Proton motive force drives biological rotary motors like Fo ATP synthase and flagellar motors.
- The bacterial type 9 secretion system (T9SS) is a third known proton motive force-driven rotary motor.
- Understanding T9SS is crucial for deciphering bacterial motility and interactions.
Purpose of the Study:
- To review the current understanding of the bacterial type 9 secretion system (T9SS).
- To discuss T9SS torque generation, its role in bacterial gliding motility, and swarm behavior.
- To identify knowledge gaps in T9SS machinery and function.
Main Methods:
- Literature review of existing research on T9SS.
- Analysis of studies on bacterial motility and secretion systems.
- Synthesis of information on T9SS structure, function, and biological impact.
Main Results:
- T9SS functions as a rotary motor, generating torque for bacterial movement.
- T9SS is integral to bacterial gliding motility and the formation of swarms.
- T9SS-mediated swarming influences microbial community structure.
Conclusions:
- The T9SS is a complex molecular machine with significant roles in bacterial physiology and ecology.
- Further research is needed to fully elucidate the T9SS machinery and its mechanisms.
- Understanding T9SS can provide insights into bacterial pathogenesis and inter-species interactions.
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