Related Experiment Video

Updated: Sep 21, 2025

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
12:42

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Published on: August 28, 2012

15.2K

The Emerging Roles and Therapeutic Implications of Epigenetic Modifications in Ovarian Cancer

Yu Wang1, Zhao Huang1, Bowen Li1

  • 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.

Frontiers in Endocrinology
|May 27, 2022
PubMed

Insights

Ovarian cancer (OC) drug resistance limits patient survival. Epigenetic modifications, including DNA methylation and non-coding RNAs, drive this resistance, suggesting epigenetic therapies could improve outcomes for OC patients.

Area of Science:

  • Oncology
  • Epigenetics
  • Gynecologic Oncology

Background:

  • Ovarian cancer (OC) is a leading cause of cancer death globally.
  • Despite initial treatment success, poor survival rates persist due to drug resistance and recurrence.
  • Molecular mechanisms of OC therapeutic resistance are under intensive investigation.

Purpose of the Study:

  • To review the role of epigenetic modifications in OC drug resistance.
  • To discuss how epigenetic changes contribute to chemoresistance.
  • To explore the clinical implications of epigenetic therapies for drug-resistant OC.

Main Methods:

  • Literature review focusing on epigenetic mechanisms in ovarian cancer.
  • Analysis of studies investigating DNA methylation, histone modifications, and non-coding RNAs in OC drug resistance.
  • Synthesis of evidence linking epigenetic alterations to chemoresistance pathways.

Main Results:

  • Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNA dysregulation, are crucial in OC drug resistance.
  • These epigenetic changes promote chemoresistance by upregulating multidrug resistance proteins, altering the tumor microenvironment, and affecting immune responses.
  • Understanding these mechanisms is key to overcoming therapeutic resistance.

Conclusions:

  • Epigenetic mechanisms play a significant role in the development of ovarian cancer drug resistance.
  • Targeting epigenetic modifications offers a promising strategy to overcome chemoresistance and improve patient outcomes.
  • Epigenetic therapies may provide novel treatment options for drug-resistant ovarian cancer.
Keywords:
DNA methylationcancer epigeneticsdrug resistanceepigenetic therapyhistone modificationsnon-coding RNAovarian cancer

More Related Videos

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.8K
Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays04:07

Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays

Published on: February 24, 2023

1.8K

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.1K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.0K
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
64.5K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K