Hematologic malignancies and COVID-19 infection: A monocenter retrospective study

Area of Science:

• Hematology
• Infectious Diseases
• Oncology

Background:

• Hematologic malignancies are established risk factors for severe COVID-19.
• Identifying mortality predictors in this patient cohort is crucial for risk assessment and management strategies.

Purpose of the Study:

• To investigate the characteristics of patients with hematologic malignancies and COVID-19.
• To analyze the predictors of mortality in this population.

Main Methods:

• Retrospective analysis of hospitalized patients with hematologic malignancies and confirmed COVID-19 infection (January 2020 - March 2021).
• Patients were categorized by malignancy type and treatment phase.
• Statistical analysis to identify factors correlated with mortality.

Main Results:

• 194 patients included; 47% overall case-fatality rate.
• Severe COVID-19 (119 patients) and ICU admission (61 patients) were common.
• Mortality predictors included male gender, preinduction/induction treatment phase, ICU admission, low oxygen saturation, Rh positivity, and elevated fibrinogen.

Conclusions:

• Patients with hematologic malignancies exhibit a high risk of mortality from COVID-19.
• Specific clinical and laboratory factors significantly correlate with increased mortality risk.