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Updated: Jun 20, 2026
08:04
Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
Published on: April 25, 2013
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Automatic Programmable Bioreactor with pH Monitoring System for Tissue Engineering Application.
Suruk Udomsom1, Apiwat Budwong1, Chanyanut Wongsa1
1Biomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand.
Bioengineering (Basel, Switzerland)
|May 27, 2022
Summary
A new programmable bioreactor with automated control and real-time pH monitoring enhances cell culture. This advanced tissue engineering technology improves cell viability and proliferation for applications like cultured meat and drug testing.
Area of Science:
- Biotechnology
- Tissue Engineering
- Cell Culture Technology
Background:
- Bioreactors are crucial for advanced tissue engineering.
- Current bioreactor systems often lack automated control and real-time monitoring capabilities.
Purpose of the Study:
- To develop a programmable bioreactor with automated component operation.
- To integrate a novel non-contact, real-time pH sensor.
- To evaluate the bioreactor's performance in cell culture.
Main Methods:
- Development of a programmable bioreactor system with automated controls.
- Integration of a new non-contact pH sensor for real-time monitoring.
- Automatic cell culture of L929 cells using the developed bioreactor.
Main Results:
- The bioreactor successfully facilitated automatic cell culture of L929 cells.
- Achieved cell viability greater than 80%.
- Demonstrated enhanced cell proliferation compared to conventional methods.
Conclusions:
- The developed bioreactor system shows potential for automated cell culture.
- The technology can advance tissue engineering products.
- Applications include cultured meat production and drug testing.
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