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Prevalence of Functional Gastrointestinal Disorders in Brazilian Infants Seen in Private Pediatric Practices and
Mauro Batista de Morais1, Mauro Sergio Toporovski2, Marise Helena Cardoso Tofoli3
1From the Division of Pediatric Gastroenterology, Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo.
Insights
Functional gastrointestinal disorders (FGIDs) are common in Brazilian infants. Prematurity significantly increases the risk for infant regurgitation, colic, dyschezia, and constipation.
Area of Science:
- Pediatrics
- Gastroenterology
- Public Health
Background:
- Functional gastrointestinal disorders (FGIDs) are prevalent in infants.
- Understanding FGID prevalence and risk factors is crucial for early intervention.
Purpose of the Study:
- To determine the frequency of common FGIDs in Brazilian infants.
- To investigate the association between FGIDs and factors like cesarean delivery, breastfeeding, and prematurity.
Main Methods:
- Cross-sectional study of 5080 infants under 12 months in Brazilian private pediatric clinics.
- Mothers completed questionnaires on delivery, feeding, prematurity, and infant GI symptoms.
- Rome IV criteria were used for FGID diagnosis.
Main Results:
- Prevalence: infant regurgitation (10.7%), colic (6.1%), dyschezia (4.0%), constipation (7.6%), diarrhea (0.09%).
- Prematurity was linked to increased odds of regurgitation, colic, dyschezia, and constipation.
- Prematurity was associated with a higher likelihood of multiple FGIDs in early infancy.
Conclusions:
- FGIDs are frequently observed in infants attending private pediatric practices in Brazil.
- A history of prematurity is a significant risk factor for several FGIDs in infants.
Objectives:
To assess the prevalence of the most frequent functional gastrointestinal disorders (FGIDs) in Brazilian infants seen in private pediatric clinics and their relationship with cesarean delivery, breastfeeding, and history of prematurity.
Methods:
This cross-sectional study enrolled 5080 infants under 12 months old with routine visits in private pediatric clinics in Brazil. The mothers answered questions about the type of delivery, type of feeding (breast milk, infant formula, cow milk, mixed feeding), history of prematurity, and gastrointestinal symptoms. Rome IV criteria were used to diagnose FGIDs.
Results:
The prevalence of infant regurgitation was 10.7% (487/4560); infant colic, 6.1% (131/2162); infant dyschezia, 4.0% (157/3895); functional constipation, 7.6% (341/4506); and functional diarrhea, 0.09% (2/2186). Prematurity was associated ( P < 0.05) with infant regurgitation (odds ratio [OR] = 1.41; 95% confidence interval [CI]: 1.05, 1.90), infant colic (OR = 1.97; 95% CI: 1.19, 3.24), infant dyschezia (OR = 1.64, 95% CI: 1.02, 2.64), and functional constipation (OR = 1.44; 95% CI: 1.02, 2.02). Prematurity was associated ( P < 0.001) with two or more FGIDs between 21 days and 150 days of age (OR = 3.06; 95% CI: 1.74, 5.37).
Conclusion:
FGIDs are common in infants seen in the private pediatric practice in Brazil. History of prematurity was associated with infant regurgitation, infant colic, functional dyschezia, and functional constipation.
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