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Related Experiment Video

Updated: Sep 21, 2025

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
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Thyroid dysfunction in Portuguese amyotrophic lateral sclerosis patients.

Cláudia Santos Silva1,2, Marta Gromicho3, Miguel Oliveira Santos4,3

  • 1Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa-Norte, 1649-035, Lisbon, Portugal. csantosilva2@gmail.com.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|May 27, 2022
PubMed
Summary

Thyroid dysfunction is less common in Amyotrophic Lateral Sclerosis (ALS) patients than in controls. This study concludes that thyroid dysfunction is not associated with the development of ALS.

Keywords:
Amyotrophic lateral sclerosisNeuromuscular diseaseThyroid dysfunction

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Area of Science:

  • Neurology
  • Endocrinology
  • Epidemiology

Background:

  • Thyroid hormones are known to affect neuromuscular function.
  • Previous research suggested a potential link between thyroid dysfunction and motor neuron degeneration.

Purpose of the Study:

  • To investigate the prevalence of thyroid dysfunction in patients with Amyotrophic Lateral Sclerosis (ALS).
  • To determine if thyroid dysfunction is associated with an increased risk of developing ALS.

Main Methods:

  • A case-control study comparing 579 ALS patients with 415 age-gender-matched controls with other neuromuscular disorders.
  • Thyroid dysfunction was identified based on endocrinologist-managed thyroid replacement medication.
  • Odds ratios (OR) with 95% confidence intervals (CI) were calculated.

Main Results:

  • Hypothyroidism prevalence was 5.0% in ALS patients versus 8.6% in controls (OR = 0.56).
  • Overall thyroid dysfunction prevalence was 5.4% in ALS patients versus 9.9% in controls (OR = 0.52).
  • These prevalences were similar to national epidemiological data for thyroid disease.

Conclusions:

  • Thyroid dysfunction was found to be less prevalent in ALS patients compared to controls.
  • The study concludes that thyroid dysfunction is not associated with Amyotrophic Lateral Sclerosis (ALS).