Effects of ambient air pollution on glycosylated hemoglobin: a systematic review and meta-analysis

Air pollution is one of the biggest environmental health problems in the world; accumulative studies have shown that air pollution was closely related to metabolism disorders. HbA1c is a stable indicator for blood glucose level monitoring. However, studies on the impact of ambient air pollution on HbA1c have inconsistent conclusions. The objective of the study is to explore the influence of ambient air pollution on HbA1c. By searching keywords, a systematic literature retrieval was carried out on PubMed, Cochrane Library, Web of Science, and Embase databases up to April 2022. Pooled percentage change (%-change) and 95% confidence intervals (95% CI) were estimated using random effect models for particulate matter (PM) and nitrogen dioxide (NO₂). A subgroup analysis of body mass index (BMI), study region, exposure period, sample size, sensitivity analysis, and publication bias detection was also performed. There were 8, 12, and 6 studies included in this meta-analysis to explore the association between PM₁₀, PM_2.5, NO₂, and HbA1c, respectively. The results showed that for every increase of 10 μg/m³ in PM₁₀, PM_2.5, and NO₂, the %-changes in HbA1c were 0.13%, 0.814%, and 0.02%, respectively. The subgroup analysis showed that exposure period, sample size, and BMI were associated with HbA1c in response to air pollution. PM₁₀, PM_2.5, and NO₂ exposure were significantly associated with increased HbA1c levels.