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IMGT® Immunoinformatics Tools for Standardized V-DOMAIN Analysis.

Véronique Giudicelli1, Patrice Duroux2, Maël Rollin2

  • 1IMGT®, the international ImMunoGenetics information system®, Laboratoire d'ImmunoGénétique Moléculaire LIGM, Institut de Génétique Humaine, (IGH), Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM), Montpellier, France. Veronique.Giudicelli@igh.cnrs.fr.

Methods in Molecular Biology (Clifton, N.J.)
|May 27, 2022
PubMed
Summary

The IMGT® system provides essential immunoinformatics tools for analyzing the diversity of immunoglobulin (IG) and T cell receptor (TR) variable domains. These tools facilitate repertoire analysis and the development of engineered IG and TR for therapeutic applications.

Keywords:
Adaptive immune repertoireAntibodyIMGTIMGT-ONTOLOGYIMGT Collier de PerlesImmunogeneticsImmunoglobulinImmunoinformaticsT cell receptorV-DOMAIN sequence analysis

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Area of Science:

  • Immunoinformatics
  • Molecular immunology
  • Genomics

Background:

  • The variable domains (V-DOMAIN) of antigen receptors, including immunoglobulins (IG) and T cell receptors (TR), exhibit extensive sequence diversity.
  • This diversity arises from complex genetic mechanisms like V(D)J recombination, N-diversity, and somatic hypermutations in IG.

Purpose of the Study:

  • To describe the suite of IMGT® online tools for characterizing and annotating expressed V-DOMAIN sequences.
  • To highlight the utility of these tools in adaptive immune response repertoire analysis and engineered receptor design.

Main Methods:

  • Utilizes IMGT/V-QUEST for detailed analysis of IG and TR rearranged nucleotide sequences.
  • Employs IMGT/HighV-QUEST for high-throughput analysis, clonotype identification, and immunoprofile generation.
  • Incorporates IMGT/StatClonotype for comparative immunoprofile analysis, IMGT/DomainGapAlign for amino acid sequence analysis, and IMGT/Collier-de-Perles for 2D V-DOMAIN structure visualization.

Main Results:

  • Provides comprehensive characterization and annotation of expressed V-DOMAIN sequences.
  • Enables detailed repertoire analyses of adaptive immune responses in various conditions.
  • Facilitates the design and engineering of IG and TR for therapeutic purposes.

Conclusions:

  • The IMGT® tools are indispensable for immunoinformatics research, offering robust capabilities for sequence analysis and structural visualization.
  • These tools significantly advance the understanding of immune receptor diversity and support the development of novel immunotherapies.